Endocrine Abstracts

Hypophosphatasia (HPP) is a genetic condition affecting teeth and bones, identified by low levels of alkaline phosphatase (ALP) activity in the blood. This deficiency is caused by mutations in the ALPL gene, leading to an accumulation of substances that hinder bone mineralization. In adults, this can result in osteomalacia, frequent fractures, premature tooth loss, and arthralgia. We describe the case of a 38 year old Caucasian woman who was 24 weeks into her third pregnancy a...

Case presentation: This detailed case report delves into the complex clinical trajectory of a 37-year-old Afro-Caribbean woman hailing from Zimbabwe, who presented with a diverse array of symptoms. Among these were diarrhea, tremor, anxiety, abdominal distension, amenorrhea and a staggering unintentional weight loss of 1 kg over the past year. Notably, her medical history features a previous open left-sided salpingectomy undertaken for a ruptured ectopic pregnancy. The persist...